Manchester: Mitch Starc, Pat Cummins and James Pattinson could play their first international match together on Tuesday as Australian selectors seek to overcome three injury casualties to seal victory in the one-day series in England.
The three exciting fast bowlers have never all been fit and in the same squad for Australia until this series.
Pattinson was overlooked for the first two matches of the series in favour of Nathan Coulter-Nile, but with the West Australian ruled out of the series with a hamstring strain and Australia also losing the seam bowling of Shane Watson (calf) selectors are unlikely to leave Pattinson out for a third consecutive match, even with John Hastings' call-up. 
The only assured selection move for the day-nighter in Manchester is Aaron Finch replacing David Warner (fractured thumb) at the top of the order.
Pattinson has not played a one-dayer since   January 2014, one of only 13 since his international debut in 2011. The departing Warner said the 25-year-old was ready to return at Old Trafford.
"Jimmy's bowling well. In the nets he's bowling quite heavy [ball] and good control. He's always a guy who's ready to go and always hungry to play for Australia or whatever team he plays for," Warner said of Pattinson. "I'm looking forward to seeing him come out if he gets the opportunity and all our players are ready to go."
Uncapped one-day duo Marcus Stoinis and Ashton Agar are likely to vie to replace Watson, ahead of his nominal replacement Peter Handscomb. Agar is approaching all-rounder status because of the progression of his batting to complement his left-arm finger spin.
Handscomb, a precocious batsman, has effectively been chosen ahead of uncapped Michael Klinger, who ranks third for Matador Cup runs over the past two seasons and on Sunday notched his eighth century of the county season to propel Gloucestershire into the one-day final.
The number of players to feature in Australia's squad since their arrival in England has grown to 29 with the inclusion of Finch, Hastings (for what would be his first international appearance since   December 2012) and Handscomb, all of whom were already in England playing county cricket.
"We looked at all options, including the possibility of flying in cover from Australia, but the fact all three of the players we have drafted in are already in England means they can join us at short notice, be acclimatised to conditions and be available for selection immediately, if required," said coach Darren Lehmann, whose team holds a 2-0 lead in the five-match series.
The departure of Coulter-Nile comes a few days after he stressed he did not have any long-term career goals "because I've never been on the park long-term", due to struggles with mainly soft-tissue injuries.
Coulter-Nile, Warner and Watson join Ryan Harris and Brad Haddin in making early departures from Australia's tour.
England have made one change to their squad. First-choice wicketkeeper Jos Buttler has been rested from the final three matches, having continued his poor batting form from the Tests in the one-dayers, and Jonny Bairstow coming into the squad in his place.
England coach Trevor Bayliss, captain Eoin Morgan and Buttler were united in their belief it was timely for the wicketkeeper to have a break.
"While we initially felt Jos would have enough left in the tank for this ODI series, it has become clear in the last couple of days that he will benefit from a break from cricket ahead of the winter tours."
ENGLAND (from): Eoin Morgan (c), Moeen Ali, Jonny Bairstow, Sam Billings, Steve Finn, Alex Hales, Liam Plunkett, Adil Rashid, Jason Roy, Ben Stokes, James Taylor, David Willey, Chris Woakes, Mark Wood.
AUSTRALIA (from): Steve Smith (c), Ashton Agar, George Bailey, Joe Burns, Pat Cummins, Aaron Finch, John Hastings, Peter Handscomb, Glenn Maxwell, Mitch Marsh, James Pattinson, Mitch Starc, Marcus Stoinis, Matthew Wade.